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Assessment of the correlations of lacosamide concentrations in saliva and serum in patients with epilepsy

Epilepsia Mar 06, 2018

Brandt C, et al. - The multi-fold aim of this research was to analyze the link between lacosamide (LCM) steady state concentrations (an antiepileptic drug) in serum and saliva samples of patients with epilepsy and to gauge the connection with daily dose, as well as to determine the feasibility of saliva collection. Data illustrated moderately lower median absolute and percentage increase of LCM in serum compared to saliva samples, with a few outliers in saliva samples. Consequently, it was reported that saliva could yield great clinical potential for the monitoring of drug concentrations and aid in LCM treatment in epileptic patients.
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