Albers GW, Lansberg MG, Brown S, et al. - During the 6- to 24-hour treatment interval, endovascular thrombectomy (EVT) was associated with equivalent benefit among patients in the clinical mismatch and target perfusion mismatch subgroups. Such findings suggest the use of EVT as a therapy option for individuals who satisfy the criteria for either of the imaging mismatch profiles within a 6- to 24-hour period.

• Among 505 eligible patients, 266 were assigned to the EVT group (mean [SD] age, 68.4 [13.8] years; 146 women [54.9%]) and 239 were assigned to the control group (mean [SD] age, 68.7 [13.7] years; 126 men [52.7%]).

• EVT was associated with lower impairment at 90 days compared with no EVT in 295 patients in the clinical mismatch subgroup and 359 patients in the target perfusion mismatch subgroup.

• Statistically significant advantages were detected in all 3 terciles for both subgroups, with the highest OR observed for tercile 3.

• In total, 132 patients (26.1%) had an undetermined imaging profile and no significant treatment benefit.

• There was a significant interaction between treatment effects for the clinical and target perfusion mismatch subgroups vs the undetermined profile subgroup.