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Assessment of diagnostic accuracy of dermoscopic structures and patterns used in melanoma detection: A systematic review and meta-analysis

JAMA Aug 09, 2021

Williams NM, Rojas KD, Reynolds JM, et al. - According to this systematic review and meta-analysis, the diagnostic value of dermoscopic structures associated with melanoma detection (eg, shiny white structures, blue-white veil) was confirmed, which adds to the overall pattern's importance and may suggest a hierarchy in the significance of these structures and patterns.

  • In total, 40 studies involving 22,796 skin lesions and 5,736 melanomas were assessed.

  • Shiny white structures, pseudopods, irregular pigmentation, blue-white veil, and peppering were the structures and patterns with the highest odds ratios.

  • Pseudopods, shiny white structures, peppering, and streaks had the highest specificity, on the other hand, irregular pigmentation, blue-white veil, atypical network, and a multicomponent pattern had the highest sensitivity.

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