Lopez-Gonzalez P, et al. - Researchers, herein, focused on the need for premedication with antihistamines and corticosteroids to prevent hypersensitivity reactions in rapid drug desensitization (RDD) to paclitaxel. They found that premedication with corticosteroids and antihistamines did not significantly impact the efficacy or safety of RDD in patients with confirmed hypersensitivity to paclitaxel but could mask early signs of hypersensitivity and delay treatment. They believed that systematic premedication with these drugs for patients undergoing RDD should be carefully and individually assessed if their only purpose is to prevent breakthrough reactions during RDD.