Chan CK, Yang WS, Lin YH, et al. - This retrospective observational cohort study was undertaken to determine if arterial stiffness estimated by brachial-ankle pulse wave velocity (baPWV) before adrenalectomy was correlated with the clinical outcomes and cardiorenal injury in lateralized primary aldosteronism (PA) patients after adrenalectomy. Lateralized PA patients undergoing adrenalectomy were obtained from the Taiwan Primary Aldosteronism Investigation database between 2013 and 2016. The study sample consisted of 221 patients with lateralized PA (50.7% men; mean age, 51.9 years), of whom 101 patients (45.7%) achieved complete clinical success at the 1-year follow-up assessment after adrenalectomy. Multifactorial adjusted generalized additive model demonstrated that preoperative baPWV<1600 cm/sec was significantly linked to complete cure of hypertension. The findings showed that preoperative severe arterial stiffness in lateralized PA patients after adrenalectomy was associated with a lack of complete clinical success, and this effect may lead to cardiorenal injury, which at least partially explains the deterioration of kidney function and reduced regression of heart mass.