Finkelstein DM, et al. – In this prospective cohort study that consisted of 16,630 adults with personal and/or family history of cancer who were recruited from cancer clinics at 14 geographically dispersed US academic centers of the NIH-sponsored Cancer Genetics Network (CGN), researchers investigated the influence of a history of rare cancer on the risk of subsequent cancer vs survivors of common cancers. Patients with a prior rare cancer displayed a 23% higher risk of subsequent cancer, while those with a prior common cancer had no excess risk vs participants who were unaffected at enrollment after a median follow-up of nearly 8 years. This finding suggested an increased risk of subsequent cancer among survivors of rare cancers, especially those with multiple cancer diagnoses.