Keet C, Plesa M, Szelag D, et al. - Since it is now advised in the US that high-risk infants should be screened for peanut allergy before introduction, but there is no clarity regarding the optimal approach, therefore, researchers compared the diagnostic test features of peanut skin prick test (SPT), peanut-specific IgE (sIgE), and sIgE to peanut components in a screening population of infants before known peanut exposure. The best discrimination betwen allergic and nonallergic was provided by Ara h 2-sIgE at a cutoff point of 0.1 kUa/L (AUC, 0.96; sensitivity, 94%; specificity, 98%), vs peanut-sIgE at 0.1 kUa/L or 0.35 kUa/L, or SPT at wheal size 3 mm or 8 mm. Based on the findings, experts recommend considering measurement of only Ara h 2-sIgE if screening of high-risk infants is done prior to peanut introduction.