Neumann JT, et al. – In this study involving 22,651 patients from 15 international cohorts who showed up to the emergency department with symptoms suggestive of myocardial infarction, researchers assessed the concentrations of high-sensitivity troponin I or high-sensitivity troponin T at presentation and post-early or late serial sampling. A significant correlation of lower high-sensitivity troponin concentrations at presentation and smaller absolute changes during serial sampling with a lower probability of myocardial infarction and a lower short-term risk of cardiovascular events was observed. A total of 56.5% of the individuals were categorized as being at low risk. Hence, to determine the probability of myocardial infarction on emergency department presentation and 30-day outcomes, a risk-assessment tool was utilized, which was formed to combine the high-sensitivity troponin I or troponin T concentration at emergency department presentation, its progressive change during serial sampling, and the time between the obtaining of samples.