Ugge H, et al. - In a population-based study including a large cohort of Swedish men, researchers assessed the link between appendicitis before age 20 and risk of later prostate cancer, presuming that immunological characteristics signaled by appendicitis before late adolescence might influence the risk of later prostate cancer. Using multivariable adjusted Cox regression analyses, HR and 95% confidence intervals (95% CIs) for the link were estimated. A statistically significant link between appendicitis and overall prostate cancer was observed. Significantly increased risk was noted for advanced and lethal prostate cancer. Overall, in regards to prostate cancer risk, the relevance of underlying immune characteristics and a pattern of inflammatory response, as potentially signalled by a diagnosis of appendicitis before adulthood, was suggested.