Nanba T, et al. – The point of this study was evaluate whether apparent brain temperature imaging applying multi–voxel proton magnetic resonance (MR) spectroscopy associates with cerebral blood flow (CBF) and metabolism imaging in the deep white matter of patients with unilateral chronic major cerebral artery steno–occlusive disease. It was revealed that apparent brain temperature imaging applying multi–voxel proton MR spectroscopy was associated with CBF and metabolism imaging in the deep white matter of patients with unilateral major cerebral artery steno–occlusive disease.