Qiu J, et al. - In this analysis, the status of anti-tuberculosis treatment in critically ill patients was investigated, and the value of APACHE-II score in guiding anti-tuberculosis treatment was explored. Researchers enrolled 320 patients (58 ± 22 years of age; 256 males), and drugs were withdrawn in 147 (45.9%). Independent factors associated with drug withdrawal comprised APACHE-II score > 18, COPD, and hemoglobin level. APACHE-II score had sensitivity, specificity, positive predictive value, and negative predictive value for predicting drug withdrawal of 59.2%, 61.8%, 56.9%, and 64.1%, respectively, at an optimal cutoff of 18.5. These findings suggested a possible predictive value of APACHE-II score > 18 points for patient tolerance of anti-tuberculosis treatment.