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Antimicrobials for the treatment of drug-resistant Acinetobacter baumannii pneumonia in critically ill patients: A systemic review and Bayesian network meta-analysis

Critical Care Evidence based | Dec 27, 2017

Jung SY, et al. - Researchers, using a Bayesian network meta-analysis, intended to determine the most effective antimicrobial strategy for the treatment of pneumonia caused by drug-resistant Acinetobacter baumannii in critically ill patients. Findings demonstrated the comparative effectiveness of 15 antimicrobial treatments. They found that sulbactam monotherapy (SUL) appeared to afford the best survival benefit followed by high-dose SUL (HD SUL), fosfomycin (FOS) + intravenous colistin monotherapy (IV COL), inhaled COL plus IV COL (IH COL + IV COL), high-dose tigecycline (HD TIG), and IV COL therapy, in numerical order.
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