Kiridly-Calderbank J, et al. - Researchers explored the link between antidepressant (AD) medication use and risk of colorectal cancer among the participants in the Women's Health Initiative. They estimated hazard ratios (HR) and 95% confidence intervals (CIs) for the link by using Cox proportional hazards regression models with adjustment for depressive symptoms and other covariates. Data showed that 6.9% of participants reported AD use at baseline. Selective serotonin reuptake inhibitors were most commonly used. No association was found between AD use, overall or by therapeutic class, and colorectal cancer risk. These data indicate that ADs are not useful as chemopreventive agents for colorectal cancer.