Shen YS, et al. - In this case report of a 69 year-old man who had blurred vision and foreign body sensation OD for many weeks, experts showed a case of corneal squamous hyperplasia diagnosed through anterior high-resolution optical coherence tomography (HR-OCT), former to surgical intervention. All the features [the comparative epithelial thickness (normal range: 47—68 μm); inferior border obscuration of epithelium (normal or benign inferior border: no shadowing); reflectivity of epithelial layer (normal: not hyper-reflective); abrupt transition (normal: no horizontally abrupt transition); and sub-epithelium analysis vary between benign and malignant lesions (normal: demarcated anterior to Bowman’s layer)] were applied to this individual as guidance, and the measurement outcomes designated the lesion to be benign in nature, which is consonant with the tissue pathology. Thus, anterior HR-OCT is overall a non-invasive and timely method competent of helping the diagnosis of ocular surface disease, prognosticating the qualities of a lesion, and ascertaining the follow-up treatment plan.