Chu C, Chen X, Hasan AA, et al. - Findings demonstrate an independent link of angiopoietin-2 (Ang-2), at baseline, with all-cause mortality in male end-stage renal disease patients undergoing hemodialysis (HD).

• In this prospective cohort study, a total of 313 HD patients (206 men and 107 women) were included.

• An AUC of 0.65 for predicting all-cause death was generated by ROC analysis of Ang-2 levels, and optimal cut-off for all-cause mortality was 111.0 pmol/l.

• A significantly lower survival was noted in male but not female end-stage kidney disease patients on hemodialysis with higher Ang-2 levels, in Kaplan-Meier survival analysis.

• In multivariable Cox regression analyses, increased Ang-2 levels were related to all-cause mortality in male (HR, 3.294) but not in female end-stage kidney disease patients on hemodialysis (HR, 1.084), as observed post-adjustments.