Hubbard R, et al. - Researchers undertook this single‐center, retrospective analysis to report the anesthetic challenges as well as the potential complications related to the management of catheter‐based closure of the ductus arteriosus in neonates under 3 kg. For anesthetic management of these patients, a clinical protocol was used. They analyzed 76 neonates who underwent 78 procedures. Perioperative hemodynamic instability, vasoactive medication needs, or acute kidney injury was not reported in any of the patients. Four patients (5%) needed red blood cell transfusion, 2 (3%) became hypothermic, and one (1%) was accidentally extubated. In 73 patients (96%), first attempt afforded closure. However, prolonged periods of mechanical ventilation after the procedure was needed in 17 patients (40%). According to the findings, multiple clinical as well as logistical challenges exist, but standardized and multidisciplinary care can afford effective management of anesthetic risk related to catheter‐based PDA closure in small neonates.