Klaewsongkram J, et al. - In the prevention and identification of the culprit drug in severe cutaneous adverse reaction (SCAR) patients, the usefulness of two strategies was assessed: HLA-B allele pre-screening and the measurement of drug-specific interferon-gamma (IFN-γ) releasing cells. Study participants were SCAR patients recruited from six university hospitals in Thailand over a 3-year period. The following drugs were found to be commonly responsible for SCARs: anticonvulsants, allopurinol, beta-lactams, anti-tuberculosis agents, and sulfonamides. Researchers concluded that only a minority of SCAR victims would be successfully prevented via HLA-B pre-screening. In almost half of patients, drug-specific IFN-γ releasing cells were detectable. There is a need for better strategies for better SCAR prevention and culprit drug confirmation.