Romano MR, Parolini B, Allegrini D, et al. - In this nonrandomized, international multicentre study involving 1,719 individuals (1,861 eyes), researchers tested the effectiveness of the different therapeutic options of central serous chorioretinopathy (CSCR) in terms of both visual (BCVA) and anatomic (OCT) improvement. Participants in the study were patients diagnosed with CSCR from 63 centres (24 countries). The odds ratio indicated a partial or complete resolution of fluid on OCT with any treatment relative to observation. A high percentage of patients have reported spontaneous resolution. Laser (micropulse and thermal) and photodynamic therapy appear to lead to significant early anatomical improvement, but little change occurs after the first month of treatment. Further clarification is needed for real visual benefit.