Balciscueta I, Barberà F, Lorenzo J, et al. - Researchers here investigated the predictive factors of outpatient laparoscopic cholecystectomy failure via performing a systematic review and meta-analysis according to Preferred Reporting Items for Systematic Reviews and Meta-analysis methodology. MEDLINE, Cochrane Library, Ovid, and ISRCTN Registry yielded 14 studies (4,194 patients) for inclusion, with a mean outpatient laparoscopic cholecystectomy failure rate of 23.4%. Following factors are identified as the predictors of outpatient laparoscopic cholecystectomy failure: age ≥ 65 years, BMI ≥ 30, American Society of Anesthesiologists score ≥ III, previous complicated biliary pathology, gallbladder wall thickening, surgical time exceeding 60 minutes, and the beginning of surgery after 1:00 pm. The knowledge concerning these factors may help surgeons in their decision-making process for the selection of suitable patients for outpatient laparoscopic cholecystectomy.