Tokic S, et al. – The investigators of this study examined the mRNA expression levels of cytotoxic T–lymphocyte antigen 4 (CTLA4), CD28, CD45, and vitamin D receptor (VDR) in T–cells, across different outcomes of Hashimoto’s thyroiditis (HT). They reported that an altered peripheral T cell mRNA profile with reduced VDR, CTLA4, CD28, and CD45RAB transcript levels was accompanied by age–related shift from naive to memory/late–differentiated T cell CD45R mRNA signature and associated with thyroid hormone status in the HT patients.