Yang C, Lei L, Pan J, et al. - This study was undertaken to investigate the role of IL-35 in CD4 ⁺ T lymphocyte and skin fibroblast (HSF) activity and cytokine levels in systemic sclerosis. Researchers collected blood and skin biopsies from 41 patients and 39 healthy controls to evaluate CD4 ⁺ T lymphocytes and IL-35-related factors. The findings revealed that in CD4 ⁺ T lymphocyte proliferation, IL-35 plays an inhibitory role but induces Treg cell differentiation by STAT1 signalling activation, HSF proliferation, and collagen expression in systemic sclerosis.