Bain KA, McDonald E, Moffat F, et al. - Among patients with alopecia areata (AA), patients with psoriatic arthritis (PsA) and healthy controls, researchers sought to provide a detailed insight into the systemic cytokine signature correlated with AA and to evaluate the relationship between cytokines and depression. To evaluate the occurrence of depression and anxiety in the cohort, the Hospital Anxiety and Depression Scale (HADS) was used. In addition to the type 17 cytokines IL-17A, IL-21, IL-23 and IL-17F, AA people have increased plasma levels of the type 2 cytokines IL-33, IL-31 and IL-17E (IL-25). Depression score is positively predicted by levels of IL-17E and IL-22. The data highlights changes in both type 17 and type 2 cytokines in people with AA, indicating that complex systemic cytokine profiles may lead to both AA pathogenesis and associated depression.