Blanke F, Oehler N, Haenle M, et al. - This study was undertaken to investigate subjective and objective clinical and magnetic resonance imaging-based radiologic outcomes after short-term follow-up in patients with focal full-size cartilage lesions of the knee joint treated with all-arthroscopic hydrogel-based autologous chondrocyte transplantation. Researchers conducted a retrospective study on patients with isolated focal cartilage defects of the knee joint who were treated with arthroscopically conducted matrix-induced autologous chondrocyte transplantation. They evaluated clinical scores at baseline and final follow-up using the Tegner Score, visual analog scale, the International Knee Documentation Committee, and the 5 subscales of the Knee Injury and Osteoarthritis Outcome Score. The study enrolled a total of 29 consecutive patients. The data exhibited that injectable matrix-induced autologous chondrocyte transplantation therapy in the knee joint led to favorable clinical and radiologic short-term results with significant improvements in all clinical scores and MOCART2.0 scores, confirming morphologic integrity of the transplanted chondrocytes. Thus, for cartilage regeneration, this minimally invasive procedure represents a promising operative technique, even for large-diameter lesions.