Researchers herein tested the hypothesis that albumin (ALB) levels are negatively linked with mortality among sepsis patients with acute kidney injury (AKI) undergoing continuous renal replacement therapy (CRRT).

• A total of 794 septic patients who were diagnosed with AKI and underwent CRRT were assessed in this secondary analysis.

• Findings suggest an independent correlation of the ALB level with prognosis for death at 28 and 90 days after CRRT initiation; a 1 g/dL rise in ALB levels was noted to be independently linked with a 25% and 27% reduction in the risk of death at 28 and 90 days, respectively.

• In subgroup analyses and tests for interactions, HCO3 and CRP were identified playing an interactive role in the association.

• ROC analysis indicated inadequacy of ALB, SOFA and APACHE-II for clinical applications when used separately.

• Researchers recommend practicing caution in considering the conclusion given the various limitations of this study.