Bodduluri S, et al. - Using multivariable regression analyses, researchers investigated correlations between airway fractal dimension (AFD) and lung function and respiratory morbidity. For this investigation, they analyzed segmented airway trees of 8,135 participants enlisted in the COPDGene cohort. The fractal dimension of the airway tree as a measure of airway remodeling in smokers is associated with respiratory morbidity, including exacerbations and decline in lung function, and informs the risk of mortality beyond the thickness of the airway wall. They suggested that fractal dimensions can be useful for phenotyping patients by providing a unique CT signature for modeling particle deposition and targeting drug delivery devices.