Rahimi K, Bidel Z, Nazarzadeh M, et al. - The effects of blood-pressure-lowering treatment on the risk of major cardiovascular events was described in groups of patients stratified by age and blood pressure at baseline.

• Included were 358,707 participants from 51 randomized clinical trials.

• Per 5 mm Hg decrease in systolic blood pressure, the hazard ratios for the risk of major cardiovascular events for the age groups were 0·82 in individuals younger than 55 years, 0·91 in those aged 55–64 years, 0·91 in those aged 65–74 years, 0·91 in those aged 75–84 years, and 0·99 in those aged 85 years and older.

• There were similar patterns of proportional risk reductions for a 3 mm Hg decrease in diastolic blood pressure.

• Variation in absolute risk reductions for major cardiovascular events was observed by age and older groups had larger absolute risk reductions.

• None of the age groups showed any clinically relevant heterogeneity of relative treatment effects across different baseline blood pressure categories.