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Age-specific prevalence and incidence of dementia diagnoses in older US adults with schizophrenia

JAMA Jun 09, 2021

Stroup TS, Olfson M, Huang C, et al. - The present study was conducted to evaluate the age-specific incidence and prevalence of dementia diagnoses among older US adults with schizophrenia and in a comparison group without serious mental illness (SMI). Between January 1, 2007, and December 31, 2017, researchers conducted a retrospective cohort study using a 50% random national sample of Medicare beneficiaries 66 years or older with fee-for-service plans and Part D prescription drug coverage. In comparison with older adults without SMI, those with schizophrenia had increased risk of receiving a diagnosis of dementia across a wide age range, possibly because of cognitive and functional deterioration related to schizophrenia or factors contributing to other types of dementia in this cohort study. Among adults with schizophrenia, high rates of dementia have implications for the course of illness, treatment, and service use.

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