Vinke PC, et al. - Among 85,618 nonobese adult participants (age 18–93 y) from the Dutch population-based Lifelines Cohort, researchers determined if age and gender could alter the strength of the link between diet quality and 4-y weight change. Using a 110-item food-frequency questionnaire, the evaluation of diet was done at baseline. They evaluated diet quality by calculating the Lifelines Diet Score, based on international evidence for diet-disease relations at the food group level. They found a link between poor diet quality and higher weight gain, particularly in young adults. Oppositely, higher weight loss was observed in relation to poor diet quality among women aged ≥ 70 y. Thus, a healthful diet represents a promising target for undesirable weight alterations in both directions.