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Age and eczema severity, but not family history, are major risk factors for peanut allergy in infancy

The Journal of Allergy and Clinical Immunology Jan 22, 2021

Keet C, Pistiner M, Plesa M, et al. - Researchers investigated peanut allergy (PA) risk prior to peanut introduction for infants suffering from (1) moderate-severe eczema, (2) another food allergy (FA), and/or (3) a first-degree relative with peanut allergy (FH). Infants aged 4 to 11 months were included, enrollment visit was completed by 321 subjects. PA was present in 18% of 195 with eczema, 19% of 59 with FA, and 4% of 201 with FH. The presence of PA was found in only 1% of 115 with FH and no eczema. Factors related to PA in those with eczema were: older age, higher SCORing Atopic Dermatitis score, black, or Asian race and suspected or diagnosed other FA. Findings revealed that infants with moderate-severe eczema commonly developed PA, whereas FH without eczema did not represent a major risk factor, this suggests that only those with significant eczema deserve screening. Introduction at later ages, even within the first year of life, was identified to be related to a higher risk of PA in those suffering from eczema, and therefore, introduction of peanut as early as possible was supported.

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