de Frutos-Lucas J, Cuesta P, Ramírez-Toraño F, et al. - This study was sought to evaluate the age and APOE genotype that affects the relationship between objectively measured physical activity and power in the alpha band, a marker of brain disease. Researchers analyzed the association between Physical activity (PA) and alpha band power in a sample of 113 healthy adults applying magnetoencephalography. Additionally, they evaluated if ε4 carriage and age modulate this association. The associations between alpha power and gray matter volumes and cognition were also tested. A parieto-occipital cluster in which PA positively associated with alpha power was detected. The relationship between PA and alpha power remained following the stratification of the cohort by genotype. The data revealed that PA could protect against the exhibiting of brain activity that defines the Alzheimer disease continuum, where it is of benefit for all individuals, particularly E3/E4 older adults.