Eldesouky L, et al. - The role of affective instability during Major Depressive Disorder (MDD) in a sample of late middle-age and older adults was examined. For this analysis, 1,630 adults aged 55-64 years completed a baseline assessment of affective instability (self-report, informant-report, interviewer-report), three assessments of MDD (computerized interview), and eight assessments of depressive symptoms (self-report) using a longitudinal design over six years. Researchers reported that affective instability was differentially related to multiple aspects of MDD's course and remained an important predictor of MDD even in older age. However, affective instability did not predict remission from depressive episodes or having more depressive symptoms over time.