Islam MM, et al. - The researchers carried out a systematic review and meta-analysis to explore the link between the long-term use of proton pump inhibitors (PPIs) and the risks of various diseases. Studies were selected via a search of Medline (PubMed), Embase, and the Cochrane Library from inception using common keywords in July 2016. Observational studies that provided risk estimates on the long-term use of PPIs and their adverse effects were included. Compared with patients who did not use PPIs, odds of community-acquired pneumonia, hip fracture, and colorectal cancer were 67%, 42%, and 55% higher in patients with long-term PPIs use. Data reported that the use of PPIs gives short-term health benefits. Prolonged use of PPIs was related to minor and also potentially major adverse health outcomes. They strongly advise that the prescription of PPIs should be done with care to improve the medication’s effectiveness and patients’ safety.