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Adverse gastrointestinal events with sodium polystyrene sulphonate and calcium polystyrene sulphonate use in dialysis patients: A nationwide registry study

Nephrology Dialysis Transplantation Dec 22, 2020

Ferreira JP, Couchoud C, Edet S, et al. - Researchers investigated dialysis patients for the occurrence of adverse gastrointestinal (GI) events (occlusion, perforation, thrombosis/ischemia) in the periods of sodium polystyrene sulphonate (SPS) or calcium polystyrene sulphonate (CPS) exposition vs the periods without exposition to ultimately ascertain the safety of these compounds which are commonly used for the treatment and control of hyperkaliemia. Patients were selected from the French National Registry and then integrated with the French hospital discharge database (between 2006 and 2017). Findings of this large, nationwide study revealed a low incidence of adverse GI events in patients receiving dialysis, and also showed that both SPS and CPS were not related to increased GI events risk.

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