Nelson S, Beveridge JK, Mychasiuk R, et al. - Via performing this longitudinal study, researchers sought to determine the categories of adverse childhood experiences (ACEs) (ie, neglect, abuse, household dysfunction in childhood) that are linked with increased risk for internalizing mental health problems, pain-related impairment, and poorer quality of life in a clinical sample of youth with chronic pain. In addition, they investigated the moderating role of posttraumatic stress symptoms (PTSS) in these correlations. At two timepoints, measures of exposure to ACEs, PTSS, depressive and anxiety symptoms, pain intensity, pain interference, and quality of life, were completed by the youth (N = 155; aged 10-18 years). Per analyses, quality of life was poorer in youth with 3+ vs 0 ACEs. Symptoms of PTSD, depression, and anxiety were higher among youth with 3+ vs 0 ACEs. Youth exposed to different types of ACEs differed in functioning. Findings suggested the moderating effect of PTSD symptoms on the association between ACEs and anxiety symptoms. The long-term functioning of youth with chronic pain was identified to be affected by ACEs.