Advanced glycation end-products increase IL-6 and ICAM-1 expression via RAGE, MAPK, and NF-κB pathways in human gingival fibroblasts
Journal of Periodontal Research Dec 04, 2017
Nonaka K, et al. - In order to explain the impact of advanced glycation end-products (AGEs) on diabetes mellitus (DM)-associated periodontitis, the researchers examined the effects of AGEs on the expression of inflammation-related factors in human gingival fibroblasts (HGFs). In HGFs, AGEs increased interleukin (IL)-6 and intercellular adhesion molecule-1 (ICAM-1) expression via the receptor for AGE (RAGE), MAPK, and NF-κB pathways. AGEs could exacerbate the progression of the pathogenesis of periodontal diseases.
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