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Advanced donor age does not increase risk of hepatocellular carcinoma recurrence after liver transplantation: A retrospective two-centre analysis using competing risk analysis

Transplant International Aug 03, 2021

Cusumano C, De Carlis L, Centonze L, et al. - To clarify the influence of donor age on the recurrence of hepatocellular carcinoma (HCC) following liver transplantation, a retrospective review was conducted of all patients transplanted for HCC in 2 European liver transplantation tertiary centres between 2002 and 2014. Researchers analyzed 728 patients transplanted with a median follow-up of 86 months. The 1-, 3- and 5-year recurrence rates were estimated to be 4.9%, 10.7% and 13.9%, respectively. Multivariable analysis revealed that the following factors were significantly related to HCC recurrence: recipient age, number of lesions, maximum size of the lesions, presence of a hepatocholangiocarcinoma and microvascular invasion. Findings demonstrated that donor age was not a risk factor for HCC recurrence. A graft from an elderly donor can be received by patients listed for HCC and it did not compromise the outcome.

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