Gupta N, et al. - In this retrospective cohort study, the researchers examined the clinicopathological data of children with adrenocortical carcinoma (ACC), identify prognostic factors, and validate a histopathological criterion to differentiate ACC from adrenocortical adenoma. They involved forty-one children, followed at the Mayo Clinic from 1950 to 2017 (onset of symptoms ≤21 years). Alive with no evidence of disease, alive with evidence of disease, and dead of disease were the outcomes of interest. The results obtained from the study indicate that the presence of metastases was an independent prognostic factor. In younger children, the Wieneke index was the most reliable in predicting clinical outcomes.