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Acute responses to diuretic therapy in extremely low gestational age newborns: Results from the Prematurity and Respiratory Outcomes Program cohort study

The Journal of Pediatrics Apr 05, 2018

Blaisdell CJ, et al. - The authors intended to figure out if daily respiratory status improved more in extremely low gestational age (GA) premature infants after diuretic exposure compared with those not exposed in modern Neonatal Intensive Care Units. The study group consisted of extremely premature infants, GAs of 230/7-286/7 weeks, enrolled in the first week of life from 13 US tertiary Neonatal Intensive Care Units. It was determined that infants in the diuretic exposed group of PROP were of lower mean GA and lower mean birth weight. Findings exhibited that the probability that the exposed infants were on a higher level of respiratory support was considerably greater for each day after the initial day of diuretic exposure compared with infants unexposed to diuretics. Thus, yielded data did not support the ability of diuretics to greatly improve the extremely premature infant's respiratory status.
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