Davy-Mendez T, et al. - Impact of initiating virologically suppressive antiretroviral therapy (ART) during acute HIV infection vs chronic HIV infection (AHI vs CHI) on CD4/CD8 ratio normalization was determined in this prospective clinical cohort study. Researchers analyzed 1198 patients [27% female and 60% African American; median age was 37 years (interquartile range 28–47) at ART initiation] with AHI and CHI between 2000 and 2015 and used Kaplan–Meier curves and multivariable Cox proportional hazards models to compare time from ART initiation to the first normal CD4/CD8 ratio (defined as CD4/CD8 ≥1). Outcomes revealed shorter time to CD4/CD8 ratio normalization in correlation with ART initiation during AHI at higher baseline CD4 cell counts and CD4/CD8 ratios.