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Acute chemical eye injury and limbal stem cell deficiency—A prospective study in the United Kingdom

Cornea Dec 09, 2018

Ghosh S, et al. - Researchers performed a prospective, consecutive, interventional single-center study of all new patients with acute chemical eye injury presenting to the Royal Victoria Infirmary Eye Emergency Department (EED) to examine the incidence, nature, outcomes, and complications of these injuries, including the incidence of limbal stem cell deficiency (LSCD). In addition, they performed a comparison of the 2 main classifications for ocular chemical injuries: Roper-Hall (RH) and Dua. Observations indicate an uncommon occurrence of acute chemical eye injuries. Work-related chemical injuries were more frequent among male patients in the working age group, whereas domestic injuries were mostly encountered among young children. A very good prognosis was noted for Grade I, II, and III RH and Dua chemical injuries treated only with topical treatment, whereas RH grade IV (Dua grade IV-VI), mainly assaults with ammonia, progressed to total/severe LSCD despite appropriate management including early amniotic membrane transplantation. The Dua classification includes conjunctival involvement which better predicts the final clinical outcome when grading chemical eye injuries.
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