Zhao L, et al. - Via conducting a randomized clinical trial involving 404 patients with chronic stable angina, experts examined the efficiency and safety of acupuncture as adjunctive therapy to antianginal therapies in decreasing the frequency of angina attacks in individuals with chronic stable angina. Participants were randomized to receive acupuncture on the acupoints on the disease-affected meridian (DAM), acupuncture on the acupoints on the nonaffected meridian (NAM), sham acupuncture (SA), or no acupuncture (wait list [WL] group). In the intention-to-treat analyses, 398 participants were included. Across the four groups, baseline features were similar. Among the groups at 16 weeks, mean changes in the frequency of angina attacks varied significantly, and a greater reduction in the number of angina attacks was noted in the DAM group vs the NAM group, in the DAM group vs the SA group, and in the DAM group vs the WL group. Therefore, compared with acupuncture on the NAM, SA, or no acupuncture (WL), acupuncture on the DAM exhibited excellent advantages in alleviating angina as adjunctive treatment to antianginal therapy.