Snast I, Kaftory R, Sherman S, et al. - Via conducting a comprehensive database search independently utilizing PubMed, Google Scholar, ScienceDirect, and the ongoing trials registry of the US National Institutes of Health, researchers sought to assess the features of acquired erythropoietic protoporphyria (EPP), a semi-dominantly inherited porphyria presenting with photosensitivity during early childhood. Twenty case reports describing 20 patients [mean age was 58 ± 13 years] were involved. According to this systematic review, most patients had photosensitivity, 20% had blistering, and 25% had hepatic insufficiency, both uncommon in EPP. The hematological disease was diagnosed after the occurrence of cutaneous symptoms in 55% of individuals. The distinct characteristics of acquired EPP was presented and emphasized that any patient presenting with new-onset photosensitivity, regardless of age should be assessed for porphyria.