Leruez‐Ville M, Ren S, Magny JF, et al. - Detailed routine ultrasound examination, performed without knowledge of maternal serology and fetal status, was compared with targeted prenatal imaging performed in prenatal diagnostic units in cases of known fetal infection regarding the ability to identify cytomegalovirus (CMV)‐infected fetuses that will develop long‐term sequelae. Researchers collected all prenatal imaging reports for 255 children with congenital CMV in a registered cohort between 2013 and 2017. Among 237 children with complete follow‐up data (> 12 months), CMV was diagnosed prenatally in 30% (71/237) and within 3 weeks after birth in 70% (166/237). Without CMV serology screening in pregnancy, only 26% of infected fetuses could be identified with routine detailed ultrasound examination that developed severe long‐term sequelae, although 64% of cases had non‐specific infection‐related findings without raising suspicion. However, a sensitivity of 91% and negative predictive value of 96% for detection of long‐term sequelae was reported for targeted ultrasound of known infected fetuses. These findings suggest inappropriateness of routine detailed ultrasound examination in pregnancy as a screening tool for congenital CMV infection that leads to long‐term sequelae. The diagnostic performance of prenatal ultrasound mainly depends on awareness of the sonologist regarding congenital CMV and knowledge of the maternal serological status in the first trimester.