Abnormal iron status is associated with an increased risk of mortality in patients on peritoneal dialysis
Nutrition, Metabolism & Cardiovascular Diseases Dec 24, 2020
Luo D, Zhong Z, Qiu Y, et al. - Researchers undertook this retrospective analysis to examine the link between iron status and death in patients undergoing peritoneal dialysis (PD). Participants were incident PD patients followed up until December 2018. Patients were split into four categories based on baseline serum transferrin saturation (percent) and ferritin concentrations (ng/ml): reference (20-30%, 100-500 ng/ml), absolute iron deficiency (<20%, < 100 ng/ml), function iron deficiency (FID) (<20%, > 100 ng/ml), and high iron (>30%, > 500 ng/ml). There were 1,173 patients in total, of those, 77.5 % exhibited iron deficiency. A median follow-up of 43.7 months was conducted. Raised risk for all-cause, but not cardiovascular (CV) mortality, was observed in the FID group vs the reference group. In addition, greater than four-fold elevated risk of both all-cause and CV mortality was noted in the high iron group. Overall, in patients receiving PD, a worse prognosis was predicted by FID and high iron.
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