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Abnormal glucose tolerance and lung function in children with cystic fibrosis. Comparing oral glucose tolerance test and continuous glucose monitoring

Journal of Cystic Fibrosis Jan 24, 2021

Elidottir H, Diemer S, Eklund E, et al. - In view of the correlation of cystic fibrosis (CF) related diabetes (CFRD) with declining lung function even before its onset and the recommendation of regular screening for CFRD using oral glucose tolerance test (OGTT), researchers here examined the utility of continuous glucose monitoring (CGM) and its concordance with OGTT. They prospectively recruited 32 patients to undergo both intermittent scan CGM (isCGM) and OGTT. These patients yielded 28 pairs of isCGMs and OGTTs. Findings revealed correlation between glucose peaks on isCGM and intermediate glucose values on OGTT. Correlation was observed between proportion of glucose > 8mmol/l on CGM and INDET values on OGTT. Lung clearance index was identified indicative of inferior lung function in children and adolescents with abnormal glucose tolerance in CF. Children and adolescents with INDET on OGTT exhibited inferior lung function.

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