Reinfjell T, et al. - Based on self-reported questionnaire studies, researchers investigated the frequency and risk factors of pain among long-term childhood cancer survivors. At the moment of their cancer diagnosis, participants aged 21 or older were included. Twenty-five studies have been identified, including five prospective cohort studies measuring pain up to 32 years after diagnosis. According to this systematic review, cancer-related pain was associated with female gender, young age at diagnosis, older age at assessment, greater time since diagnosis, specific diagnoses (ie, central nervous system tumours, bone tumours and sarcoma), fatigue and persistent emotional distress. Migraines, headaches and back pain were the most common types of pain. A subset of survivors of childhood cancer reported self-reported pain that was clinically important. For developing tailored intervention and prevention strategies, identifying survivor subgroups at risk for pain could be essential. Prospective studies are needed to assess pain using standardized and psychometrically sound tools.