Momon A, et al. - Researchers performed this single-center, randomized, double-blind, and double-dummy trial investigating if early mobilization after spinal surgery could be improved by the analgesic effect of adding preoperative pregabalin, at a dose unlikely to induce side effects, to preoperative dexamethasone. The study cohort comprising a total of 160 patients undergoing scheduled lumbar disk surgery (145 analyzed) was administered either 0.2 mg/kg intravenous dexamethasone before incision, or 150 mg oral pregabalin 1 hour before surgery, or a combination of the 2, or none of the above (control). Analgesia was supplemented by acetaminophen and ketoprofen, plus oxycodone ad libitum. Outcomes suggest that in this surgical model with the given anesthetic and analgesic environment, the addition of low-dose pregabalin or dexamethasone resulted in no benefit. The size of the effect might have reduced with the multimodal analgesic protocol applied to all patients.