Ninomiya K, Yokoyama T, Hotta K, et al. - This study attempted to explore if sodium alginate has preventative effects on esophagitis in patients with non-small-cell lung cancer (NSCLC) receiving concurrent chemoradiotherapy (CRT). Researchers randomized 94 patients with untreated stage III NSCLC who were eligible for concurrent CRT were randomly assigned at a 1:1:1 ratio to receive one of the following treatments: initial or late use of oral sodium alginate (arms A and B) or water as control (arm C) between February 2014 and September 2018. The primary outcome included the proportion of patients developing G3 or worse esophagitis. Overall, 94 patients were randomly assigned between February 2014 and September 2018. In patients with NSCLC, sodium alginate did not show significant preventative effects on radiation-induced esophagitis. It was shown that the frequency of CRT-induced febrile neutropenia was lower in the early use of sodium alginate arm.