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A randomized, evaluator‐blinded comparative study of a potassium titanyl phosphate (KTP) 532‐nm picosecond laser and an alexandrite 755‐nm picosecond laser for the treatment of solar lentigines in Asians

Journal of Cosmetic Dermatology Feb 11, 2022

Based on the findings, it was inferred that both the KTP 532-nm picosecond laser and the alexandrite 755-nm picosecond laser may be employed to treat solar lentigines. Achievement of a successful outcome depends on proper treatment settings and endpoint observation.

  • This study included 30 patients who had at least two solar lentigines on their arms; 30 paired lentiginous lesions were randomly selected for a single treatment with either a KTP 532-nm picosecond laser or an alexandrite 755-nm picosecond laser.

  • Treatment efficacy was measured by assessing the mean luminance score (L*) at baseline and at six, and 12 weeks.

  • Significant improvement in mean L* from baseline was achieved with both types of picosecond laser.

  • At 12 weeks follow-up, greater improvement in mean L* was observed in lesions treated with the alexandrite 755-nm picosecond laser than treatment with the KTP 532-nm picosecond laser.

  • In the alexandrite 755-nm picosecond laser and KTP 532-nm picosecond laser groups, more than 50% improvement occurred in 25 and 19 lesions, respectively.

  • No difference in adverse events were observed between groups.

  • The alexandrite 755-nm picosecond laser was associated with a significantly higher satisfaction score at the last visit.

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