Aggarwal N, et al. - This research aspired to determine if buspirone improves manometric parameters and symptoms in patients with overlapping Ineffective Esophageal Motility (IEM)/Functional Dysphagia (FD). In IEM/FD patients treated with buspirone, the physicians found no difference in terms of high-resolution esophageal manometry (HREM) parameters or symptom scores compared to placebo, despite previous data demonstrating improved esophageal motility in healthy volunteers. To identify novel agents for this condition, further research was necessary.